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As our understanding of the brain’s physiology and pathology progresses, increasingly sophisticated technologies are required to advance discoveries in neuroscience and develop more effective approaches to treating brain disease. There is a tremendous need for advanced materials solutions at the biotic/abiotic interface to improve the spatiotemporal resolution of neuronal recording and stimulation. Organic electronic devices offer a unique approach to these challenges, due to their mixed ionic/electronic conduction, mechanical flexibility, enhanced biocompatibility, and capability for drug delivery.

Khodagholy and fellow researchers designed, developed, and characterized conformable organic electronic devices in the form of electrodes, ion gated transistors, conformable batteries, and ionic communication units to efficiently interface with the brain and acquire neurophysiological activity not previously accessible with recordings from the brain surface. These devices have facilitated large-scale rodent neurophysiology experiments and uncovered a novel oscillatory interaction. The biocompatibility of the devices allowed intra-operative recording from patients undergoing epilepsy and deep brain stimulation surgeries, highlighting the translational capacity of this class of neural interface devices.